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December 03, 2024
RESPIRATORY HEALTH
The Need
- Respiratory viruses, especially influenza, mutate rapidly and novel strains can emerge with little notice.
- Sensitivities of Rapid EIA Flu tests range from 50-70%1
- This genetic evolution can potentially impact the performance of molecular diagnostic tests if mutations occur within the test’s targeted regions.2
(1) CDC. Information for Clinicians on Rapid Diagnostic Testing for Influenza. https://www.cdc.gov/flu/professionals/diagnosis/rapidclin.htm#:~:text=Sensitivities%20of%20rapid%20 influenza%20diagnostic%20tests%20are%20low,culture%20or%20reverse%20transcription%20polymerase%20chain%20reaction%20%28RT-PCR%29. Accessed June 2023.
(2) Jørgensen RL, Lerche CJ, Pedersen MS, Kirkby NS, Botnen AB, Trebbien R, Nilsson-Møller S, Pinholt M,Nielsen ACY, Westh H, Lisby JG, Schneider UV. Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: be alert of false-negative test results. APMIS. 2022; 130: 612–617.
(2) Jørgensen RL, Lerche CJ, Pedersen MS, Kirkby NS, Botnen AB, Trebbien R, Nilsson-Møller S, Pinholt M,Nielsen ACY, Westh H, Lisby JG, Schneider UV. Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: be alert of false-negative test results. APMIS. 2022; 130: 612–617.
The Solution
Cepheid’s Xpert Xpress Flu test utilizes a multi-target approach for the detection of influenza, providing target redundancy to mitigate potential impact of genetic shift and drift on strain detection.
Accurate and reliable detection of Flu A and Flu B in as soon as 20 minutes*
Accurate and reliable detection of Flu A and Flu B in as soon as 20 minutes*
- Accurate and reliable detection of Flu A and Flu B in as soon as 20 minutes*
- Enables healthcare providers to quickly deliver targeted therapies
- Streamlines laboratory operations
* With early assay termination for positive results, full run time is approximately 30
The Impact
A single‑test workflow may support laboratory efficiency with on‑demand, random‑access testing. Combine performance with the capability to run other Xpert® tests on Cepheid’s GeneXpert® system may support laboratory workflow efficiency across overall laboratory services.
Be Proactive
Be Proactive
- Achieve rapid results to support patient management workflows
- Early assay termination option: deliver positive results in as soon as 20 minutes* and negative results in 30 minutes
- Quickly deliver results to support informed clinical decision‑making
* With early assay termination for positive results, full run time is approximately 30 mins.