Video
3m Watch
September 10, 2024
ANTIMICROBIAL STEWARDSHIP
The Need
- Burden – Acute gastroenteritis remains a leading cause of morbidity, mortality, and healthcare visits1
- Clinical Presentation – Bacterial, viral, and parasitic pathogens may cause similar symptoms leading to difficulty distinguishing between infectious etiologies based on the clinical presentation alone1
- Diagnosis - Conventional methods for the identification of gastrointestinal pathogens are time-consuming, expensive, and have limited sensitivity2
1. Binnicker MJ.2015.Multiplex Molecular Panels for Diagnosis of Gastrointestinal Infection: Performance, Result Interpretation, and Cost-Effectiveness. J Clin Microbiol53:.https://doi.org/10.1128/jcm.02103-15
2. Beal SG, Tremblay EE, Toffel S, Velez L, Rand KH2018.A Gastrointestinal PCR Panel Improves Clinical Management and Lowers Health Care Costs. J Clin Microbiol56:10.1128/jcm.01457-17.https://doi.org/10.1128/jcm.01457-17
2. Beal SG, Tremblay EE, Toffel S, Velez L, Rand KH2018.A Gastrointestinal PCR Panel Improves Clinical Management and Lowers Health Care Costs. J Clin Microbiol56:10.1128/jcm.01457-17.https://doi.org/10.1128/jcm.01457-17
The Solution
- Fast and accurate detection of GI pathogens is important so that appropriate therapy can be initiated and proper infection control and epidemiologic measures can be taken to help reduce or prevent the spread of disease1
- Standardized, streamlined workflow: The Xpert® GI Panel is clinically tailored to identify common pathogens causing suspected gastrointestinal infection3,4 with quick actionable, accurate results within approx. 74 minutes
1.Binnicker MJ.2015.Multiplex Molecular Panels for Diagnosis of Gastrointestinal Infection: Performance, Result Interpretation, and Cost-Effectiveness. J Clin Microbiol53:.https://doi.org/10.1128/jcm.02103-15
3. Shane AL et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis 2017
4. CDC Yellow Book 2024 | Travelers' Health | CDC Travelers’ Diarrhea, https://www.cdc.gov/yellow-book/hcp/preparing-international-travelers/travelers-diarrhea.html
3. Shane AL et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis 2017
4. CDC Yellow Book 2024 | Travelers' Health | CDC Travelers’ Diarrhea, https://www.cdc.gov/yellow-book/hcp/preparing-international-travelers/travelers-diarrhea.html
The Impact
- Fast and accurate identification of causative GI pathogens enables clinicians to avoid unnecessary testing and medical procedures while enabling appropriate interventions earlier 2,5
- Targeted, mid-plex panels capture meaningful proportions of clinically relevant targets while reducing over- or co-detection of pathogens with limited clinical relevance6
2. Beal SG, Tremblay EE, Toffel S, Velez L, Rand KH2018.A Gastrointestinal PCR Panel Improves Clinical Management and Lowers Health Care Costs. J Clin Microbiol56:10.1128/jcm.01457-17.https://doi.org/10.1128/jcm.01457-17
5.Moon RC, et al. 2023. Relationship between Diagnostic Method and Pathogen Detection, Healthcare Resource Use, and Cost in U.S. Adult Outpatients Treated for Acute Infectious Gastroenteritis. J Clin Microbiol.
6. Chase et al., 2025.. Comparison of Target Detection Rates of Multiplex Gastrointestinal PCR Panels: A Systematic Literature Review and Meta-analysis. ID week abstract
5.Moon RC, et al. 2023. Relationship between Diagnostic Method and Pathogen Detection, Healthcare Resource Use, and Cost in U.S. Adult Outpatients Treated for Acute Infectious Gastroenteritis. J Clin Microbiol.
6. Chase et al., 2025.. Comparison of Target Detection Rates of Multiplex Gastrointestinal PCR Panels: A Systematic Literature Review and Meta-analysis. ID week abstract