Xpert HCV VL Fingerstick

Xpert® HCV VL Fingerstick

Hepatitis C Testing and Linkage to Care

  • The Xpert HCV VL Fingerstick test is an exciting new tool which simplifies HCV testing so that patients can receive their results on-site in less than an hour in a single visit. This reduces waiting times for results and offers the opportunity to enhance linkage to care and initiate HCV treatment on the same day. This may be particularly useful for remote/regional settings and among people who inject drugs.”

    Associate Professor Jason Grebely, BSc PhDThe Kirby Institute, UNSW Sydney, Australia

    The Goal

    Elimination of Hepatitis C by 2030

    Viral hepatitis is one of the leading causes of death globally with 1.34 million deaths per year, as many as HIV/AIDS, tuberculosis or malaria. Both hepatitis B and C viruses cause 80% of liver cancer cases in the world.1

    The WHO global health sector strategy to eliminate Viral Hepatitis C as a major public health threat by 2030 identifies the key role of diagnostics and linkage to care.2

    • Individuals at highest risk of transmitting HCV, such as people who inject drugs, prisoners, and men who have sex with men, have poor access to testing and therefore treatment.2
    • Complicated multi-step diagnostic pathways based on antibody screening and RNA confirmation take time and represent barriers that discourage at risk populations from testing.3,4,5

    The Need

    Simplification of the diagnostic pathway to improve linkage to care

    • Until now, confirmation of a positive antibody-based test requires venepuncture, preparation and transport of blood specimens, laboratory expertise, and days/weeks to obtain results.4
    • A final diagnosis of active HCV infection may require up to 5 visits.3
    • A simple one-step pathway, with a fast RNA diagnostic at the point of care, may have the potential to simplify testing algorithms, increase diagnosis rates, and lead to increased linkage to care.

    (1) Mohd Hanafiah K, et al. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57(4): 1333-42. (2) WHO. Hepatitis C Fact Sheet N° 164. Updated April 2014. Accessed April 2015 at http://www.who.int/mediacentre/factsheets/fs164/en/; (3) Ghany MG, et al. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009 Apr;49 (4):1335-74. (4) Graham CS, et al. A Path to Eradication of Hepatitis C in Low-and-Middle-Income Countries. Antiviral Res. 2015 Jan 20; pii: S0166-3542(15)00005-4. [Epub ahead of print].

    The Solution

    Xpert HCV VL Fingerstick on the GeneXpert® System

    • Collect a drop of blood via fingerstick, transfer the blood to a test cartridge and run the test.
    • Fast diagnosis of HCV RNA from capillary whole blood and venous blood samples
    • Flexible and portable system, thanks to a cartridge-based design.
    • Quantitative RNA results available in less than 1 hour at the point of care.