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Xpert® MRSA/SA Blood Culture

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Xpert® MRSA/SA BC (10-test kit)

GXMRSA/SABC-CE-10

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Questions fréquentes

1. What is the Xpert® MRSA/SA Blood Culture test?

1. What is the Xpert® MRSA/SA Blood Culture test?

The Xpert® MRSA/SA Blood Culture test, performed on the GeneXpert® systems, is a qualitative in vitro diagnostic test intended for the detection of Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA) DNA directly from positive blood cultures.1

2. How does the Xpert® MRSA/SA Blood Culture test work?

2. How does the Xpert® MRSA/SA Blood Culture test work?

The test utilizes automated real-time polymerase chain reaction (PCR) for the amplification of MRSA/SA specific DNA targets and fluorogenic target-specific hybridization probes for the real-time detection of the amplified DNA.1

3. What is the indicated use for the Xpert MRSA/SA Blood Culture test?

3. What is the indicated use for the Xpert MRSA/SA Blood Culture test?

The Xpert MRSA/SA Blood Culture test is indicated for use in conjunction with other laboratory tests, such as culture, and clinical data available to the clinician as an aid in the detection of MRSA/SA from positive blood cultures. Subculturing of positive blood cultures is necessary to recover organisms for susceptibility testing or for epidemiological typing. The Cepheid Xpert MRSA/SA Blood Culture test is not intended to monitor treatment for MRSA/SA infections.1

4. What is Staphylococcus aureus (SA) and MRSA?

4. What is Staphylococcus aureus (SA) and MRSA?

Staphylococcus aureus (SA) is a human pathogen, which is the causative agent of a range of diseases including bacteremia, endocarditis, osteomyelitis, toxic shock syndrome, food poisoning, carbuncles, and boils.1

In the early 1950s, acquisition and spread of beta-lactamase-producing plasmids thwarted the effectiveness of penicillin for treating SA infections. In 1959, methicillin, a semi-synthetic penicillin, was introduced and, soon after, methicillin-resistant SA (MRSA) strains were identified.1

5. How does being colonized with MRSA impact the likelihood of developing MRSA infections?

5. How does being colonized with MRSA impact the likelihood of developing MRSA infections?

MRSA colonization increases the risk of infection, with infecting strains match colonizing strains in as many as 50–80% of cases. MRSA nasal colonization rates range from 0,9% to 1,5% in the United States2

Références :

 

1. Xpert® MRSA/SA Blood Culture Package Insert. Consulté le 9/25/2024.  https://www.cepheid.com/fr-CHntent/dam/www-cepheid-com/documents/package-insert-files/301-1061-mrsa-sa-bc/IFU%20MRSA.SA%20BC%20ENGLISH%20301-1061%20Rev%20F.pdf


2. Turner, N.A., Sharma-Kuinkel, B.K., Maskarinec, S.A. et al. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol 17, 203–218 (2019). https://doi.org/10:1038/s41579-018-0147-4

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