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Xpert® C. difficile BT
Detection of Clostridium difficile infection with an independent call-out of binary toxin and differentiation of the 027 strain in around 45 minutes
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10 Tests
GXCDIFFBT-CE-10
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Collection devices
Collection Device (Pack of 50)
900-0370
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Single Use Disposable Swab (Pack of 120)
SDPS-120
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The Need
C. difficile infections (CDI) have been increasing in incidence and severity, and are associated with an increase in length of hospital stay, costs, morbidity and mortality.2
- Highly virulent (027-NAP1-BI) strains have caused outbreaks of severe disease in Europe and North America3
- Binary toxin (BT) may be important because of:
- Links to both disease severity and outcome4
- Strains such as 033 are positive only for binary toxin and not toxins A and B, yet have caused CDI5,6
(2) European Hospital and Healthcare Federation (HOPE). CDI Europe Report, 2013: Clostridium difficile infection in Europe. FDX/12/0082/EU.(3) Marujo V, et al. The largely unnoticed spread of Clostridioides difficile PCR ribotype 027 in Germany after 2010. IPIP. 2020 Dec;2(4):100102.(4) Stewart D, et al. Predicting recurrence of C. difficile colitis using bacterial virulence factors: binary toxin is the key. J Gastrointest Surg. 2013 Jan;17(1):118-24.(5) Eckert C, et al. Prevalence and pathogenicity of binary toxin-positive C. difficile strains that do not produce toxins A and B. New Microbes New Infect. 2014 Nov;8(3):12-7.(6) Androga G, et al. Evaluation of the Cepheid Xpert C. difficile/Epi and meridian bioscience illumigene C. difficile assays for detecting Clostridium difficile ribotype 033 strains. J Clin Microbiol. 2015 Mar;53(3):973-5.(7) Tresman R & Goldenberg S. Healthcare resource use and attributable cost of Clostridium difficile infection: a micro-costing analysis comparing first and recurrent episodes. J Antimicrob Chemother. 2018 Oct;73(10):2851-2855.
The Solution
CDI has become a substantive and growing burden in hospitalised patients prompting the need for earlier and accurate detection.
Xpert® C. difficile BT enables:
Xpert® C. difficile BT enables:
- Fast identification of toxin-producing C. difficile in around 45 minutes
- Broad coverage with multiple targets, including: toxin B (tcdB), binary toxin (cdtA), and the tcdC deletion at base 117 associated with the ribotype 027 strain, a predictor of severe CDI and mortality8
- Optimised and prompt administering of therapy to support improved patient outcomes9
- Timely infection control initiatives to reduce the spread of infection10
- Laboratory efficiencies with on-demand workflows requiring minimal hands-on time and no repeat testing1,11
(1) Casari E, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resist Infect Control. 2018 Mar;7(40).(8) Rao K, et al. C. difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin Infect Dis. 2015 Jul 15;61(2):233-41.(9) Peppard W, et al. Implementation of polymerase chain reaction to rule out C. difficile infection is associated with reduced empiric antibiotic duration of therapy. Hosp Pharm. 2014 Jul;49(7):693-43.(10) Schroeder L, et al. Economic evaluation of laboratory testing strategies for hospital-associated Clostridium difficile infection. JCM. 2014 Feb;52(2):489.(11) Following C. difficile sampling guidance detailed in: McDonald L, et al. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018 Apr;66(7):e1–e48.CATALOG INFORMATION Xpert® C. difficile BT10 tests GXCDIFFBT-CE-10
The Impact
On-demand answers, anywhere and anytime your patients need care
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