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Xpert® MTB/RIF Ultra

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MTB/RIF Ultra computer generated depiction.
Detection of Mycobacterium tuberculosis complex and Rifampin-resistance associated mutations in less than 80 minutes

The Need

an ill woman listens to a physician
  • Each day, close to 4,400 people lose their lives to TB and nearly 30,000 people fall ill with this preventable and curable disease1
  • Globally, diagnosis of TB and drug-resistant TB remains a challenge, with a third of people with TB and two-thirds of people with drug-resistant TB not being detected1
  • Precise and early detection of TB is needed to improve case management and significantly enhance the prevention of TB transmission2
1 World Health Organization Tuberculosis Report 2023 - https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023
2 Centers for Disease Control and Prevention—Guidelines for preventing the transmission of TB - https://www.cdc.gov/mmwr/preview/mmwrhtml/00001897.htm

The Solution

a male and a female researchers scanning cepheid test cartridges
  • Xpert MTB/RIF Ultra provides fast and highly accurate detection of Mycobacterium Tuberculosis (MTB) and Rifampicin (RIF) resistance simultaneously from patient samples
  • Higher sensitivity, especially in smear-negative TB cases and among HIV-infected patients3
  • Simple three-step process with minimal hands-on time and results in ~80 min direct from sample
  • Designed to provide highly accurate MTB and Rifampicin detection utilizing multi-target and melt curves technology
3 Aliasgar Esmail, et al, Comparison of Xpert MTB/RIF (G4) and Xpert Ultra, including trace readouts, for the diagnosis of pulmonary tuberculosis in a TB and HIV endemicsetting https://researchonline.lshtm.ac.uk/id/eprint/4661245/1/1-s2.0-S1201971220301442-main.pdf

The Impact

a smiling female doctor attends an elderly woman
  • Early detection of MTB and RIF resistance can support timely clinical decision‑making and appropriate therapy initiations4
  • IIncreased access to front‑line testing with Xpert MTB/RIF Ultra as part of active case finding and management can help support control activities5
  • Superior sensitivity to smear microscopy enables detection of more MTB‑positive patients, with results available in ~80 minutes to support prompt clinical assessment
4 Charkravorty S, et al. The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing - https://journals.asm.org/doi/10.1128/mbio.00812-17
5 Belén Saavedra, et al. Performance of Xpert MTB/RIF Ultra for tuberculosis diagnosis in the context of passive and active case finding - https://erj.ersjournals.com/content/58/6/2100257

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