Accurate Detection of MRSA and SA in Positive Blood Culture Specimens in About an Hour

Ordering Info
  • In an era of escalating antimicrobial resistance and lack of new antibiotic discovery, the most efficacious and timely method for S. aureus bacteremia detection and antibiotic therapy with de-escalation are needed. The Xpert MRSA/SA BC test, in conjunction with an ID PharmD intervention, provides increased clinical and economic benefits.

    Debra Goff, PharmD. Infectious Disease Specialist
    The Ohio State University Medical Center

    The Need

    Bloodstream infections are a major healthcare concern:

    • Severe sepsis strikes 750,000 people annually in the U.S., resulting in mortality rates of up to 200,000 per year.1 Methicillin-resistant Staph aureus (MRSA) and Staph aureus (SA) are the causative pathogen in up to 35% of severe sepsis cases.2
    • Current culture-based lab testing methods for gram positive blood culture bottles require an additional 18-48 hours for determination of MRSA or SA.
    • Without timely results, clinicians often employ empiric treatments, using costly and inadequate antimicrobials that contribute to increased drug resistance.

    (1) http://www.ihi.org/explore/Sepsis/Pages/default.aspx;
    (2) Septic Shock; The Lancet; January 2005

    The Solution

    On-demand molecular testing — an ideal solution:

    • Accurate molecular detection of MRSA or SA from a gram-positive blood culture sample in about an hour
    • Simple test protocol can be run on all shifts to provide results around-the-clock
    • Provides clinicians actionable information when it is most needed
    • Easily integrates into institution septic bundle processes

    The Impact

    A recent clinical study3 showed that using the Xpert MRSA/SA BC test coupled with an infectious disease pharmacist consultation resulted in:

    • Switch to optimum antimicrobial therapy 1.7 days sooner
    • Mean length of stay was reduced 6.2 days
    • Mean hospital costs were $21,387 less per bacteremic patient

    (3) Goff, D et al. An Antimicrobial Stewardship Program’s Impact with Rapid Polymerase Chain Reaction Methicillin-Resistant Staphylococcus aureus/S. aureus Blood Culture Test in Patients with S. aureus Bacteremia. Clin.Infect. Dis. November 2010.

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    • Catalog #:

      Xpert MRSA/SA BC
      Number of Tests: 10