Accurate Detection of MRSA and SA in Positive Blood Culture Specimens in About an Hour

  • In an era of escalating antimicrobial resistance and lack of new antibiotic discovery, the most efficacious and timely method for S. aureus bacteremia detection and antibiotic therapy with de-escalation are needed. The Xpert® MRSA/SA BC test, in conjunction with an ID PharmD intervention, provides increased clinical and economic benefits.”

    - Debra Goff, PharmD. Infectious Disease Specialist
    The Ohio State University Medical Center

    The Need

    Bloodstream infections are a major healthcare concern:

    • 20 to 30 million patients are estimated to be afflicted by sepsis every year in the world.1 In Europe, the mortality rate in the Intensive Care Units (ICU) is 27%.2 Methicillin-resistant Staph aureus (MRSA) and Staph aureus (SA) are the causative pathogen in up to 35% of severe sepsis cases.3
    • Current culture-based lab testing methods for gram positive blood culture bottles require an additional 18-48 hours for determination of MRSA or SA.
    • Without timely results, clinicians often employ empiric treatments, using costly and inadequate antimicrobials that contribute to increased drug resistance.

    (1) http://www.world-sepsis-day.org/; (2) Vincent, et al. on behalf of the Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 2006 Vol. 34, No. 2.; (3) Septic Shock; The Lancet; January 2005.

    The Solution

    On-demand molecular testing — an ideal solution:

    • Accurate molecular detection of MRSA or SA from a gram-positive blood culture sample in about an hour
    • Simple test protocol can be run on all shifts to provide results around-the-clock
    • Provides clinicians actionable information when it is most needed
    • Easily integrates into your hospital’s bundle of sepsis interventions

    The Impact

    A recent clinical study4 showed that using the Xpert MRSA/SA BC test coupled with an infectious disease pharmacist consultation resulted in:

    • Switch to optimum antimicrobial therapy 1.7 days sooner
    • Mean length of stay was reduced 6.2 days
    • Mean hospital costs were €15,643 less per bacteremic patient

    (4) Goff, D et al. An Antimicrobial Stewardship Program’s Impact with Rapid Polymerase Chain Reaction Methicillin-Resistant Staphylococcus aureus/S. aureus Blood Culture Test in Patients with S. aureus Bacteremia. Clin.Infect. Dis. November 2010.