Dealing with the Complexity of a Living Target

Friday, December 23, 2016 Published in On-Demand Fall 2010 Written by Ellen Jo Baron, Ph.D., D(ABMM), Prof. Emerita, Stanford University Director of Medical Affairs, Cepheid

CONCEPTS OF SENSITIVITY AND CONFIDENCE INTERVALS OF A NEW TEST RELATED TO COMPARATIVE (REFERENCE) ASSAYS

Example: Clostridium difficile tests

In their interpretation of laboratory test results, potentially risky practice patterns have been observed among some clinicians. If a laboratory test yields a positive result, clinicians tend to believe it and make treatment decisions based on that result. However, if the test result is negative but does not match their initial clinical impression, clinicians tend to discount the test result and continue their empiric therapy regimen or repeat the test to “prove” their initial diagnosis. Microbiologists often observe this phenomenon by examining physician ordering behavior with laboratory tests for Clostridium difficile.

The Cepheid HAI Consortium (A User-Based Resource)

Friday, December 23, 2016 Published in On-Demand Fall 2010 Written by Fred C. Tenover, Ph.D., D(ABMM), Senior Director for Scientific Affairs and Consortium Director

INTRODUCTION

The theme of the Cepheid Healthcare Associated Infection (HAI) Consortium is “Our Customers as Collaborators.” Our vision is to enlist our customers as partners to answer key questions about the changing epidemiology of healthcare-associated infections and resistance patterns of HAI-associated microorganisms. Consortium members provide Cepheid with organisms of interest during defined time periods. All isolates Cepheid receives have been de-identified and coded so that there is no link to patients’ protected health information. We have received and studied more than 500 isolates to date. The results of our studies are not only of scientific interest but they help Cepheid keep abreast of changing strain patterns that may influence our Xpert® assays. This has been particularly helpful in addressing the changing epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolates with the recognition of both “empty cassette” strains (where mecA is lost from the SCCmec cassette) and the emergence of SCCmec variants.

On-Demand Newsletter, Spring 2010

Friday, December 23, 2016 Published in On-Demand Spring 2010 Written by Cepheid

Cover Story: Two Premier Seattle Hospitals Opt for Rapid Clostridium difficile Results

Inside: Lancet Laboratories, South Africa, Renovates its TB Processing with implementation of Rapid PCR Assay

On-Demand Newsletter, Winter 2010

Friday, December 23, 2016 Published in On-Demand Winter 2010 Written by Cepheid

Cover Story: Good medicine is good economically, too

Inside: Summaries of selected abstracts presented at three recent meetings: Infectious Diseases Society of America (IDSA); Association for Molecular Pathology (AMP); Réunion interdisciplinaire de chimiothérapie anti-infectieuse (RICAI)

On-Demand Newsletter, Fall 2009

Friday, December 23, 2016 Published in On-Demand Fall 2009 Written by Cepheid

Cover Story: Influenza Hijacks Laboratory Efforts Worldwide

Inside: Neonatal Early Onset Group B Streptococcol Disease May Have Met Its Match

On-Demand Newsletter, Summer 2009

Friday, December 23, 2016 Published in On-Demand Summer 2009 Written by Cepheid

Cover Story: Outbreak! The New Clostridium difficile

Inside: Vancomycin-Resistant Enterococci— Still Here, Still a Problem

From The Editor: David Persing, M.D., Ph.D.

On-Demand Newsletter, Spring 2009

Friday, December 23, 2016 Published in On-Demand Spring 2009 Written by Cepheid

Cover Story: The Decolonization Decision In A New Healthcare Paradigm

Inside: Rapid Results Pay Off for Patients and Healthcare Systems

On-Demand Newsletter, Winter 2008

Friday, December 23, 2016 Published in On-Demand Winter 2008 Written by Cepheid

Cover Story: A New Paradigm for the Management of Skin and Soft Tissue Infections (SSTI) in the Era of MRSA

Inside: Highlights from ICAAC/IDSA A Summary of Selected Presentations with a Focus on Healthcare-Associated Infections

On-Demand Newsletter, Summer 2008

Friday, December 23, 2016 Published in On-Demand Summer 2008 Written by Cepheid

Cover Story: Universal testing program with the GeneXpert® system optimizes MRSA control efforts

Inside: Clostridium difficile: A Difficult Diagnosis

From The Editor: David Persing, M.D., Ph.D.

On-Demand Newsletter, Fall 2008

Monday, September 22, 2008 Published in On-Demand Fall 2008 Written by Cepheid

Cover Story: New England Baptist Hospital: Testing Patients for MRSA and Staph aureus Before Inpatient Surgery

Inside: Celebration of the 30th Anniversary of Clostridium difficile; A summary of selected presentations from the 9th Biennial Congress of the Anaerobe Society of the Americas

From The Editor: David Persing, M.D., Ph.D.